Cold Spring Harbor Laboratory is hosting the course, “Statistical Analysis of Genome Scale Data,” from June 6-20, 2025. Harmen Bussemaker, from Columbia University, Sean Davis, from the University of Colorado Anschutz School of Medicine, Hans Tomas Rube, from the University of California Merced and Min Zhang, from the University of California, Irvine will serve as the course instructors. The class focuses on building competence in statistical methods for analyzing high-throughput data in genomics and molecular biology in both experimental and computational biologists through detailed lectures and presentations by instructors and guest speakers and hands-on computer tutorials. The guest speakers for 2025 are Leonardo Collado Torres, from the Lieber Institute for Brain Development, Ludwig Geistlinger, from Harvard Medical School, Jussi Taipale, from University of Cambridge and Julia Zeitlinger, Stowers Institute for Medical Research.
Topics include:
- The R environment for statistical computing and graphics
- Introduction to Bioconductor
- Review of basic statistical theory and hypothesis testing
- Experimental design, quality control, and normalization
- High-throughput sequencing technologies
- Expression profiling using RNA-Seq and microarrays
- In vivo protein binding using ChIP-Seq
- High-resolution chromatin footprinting using ATAC-seq
- Integrative analysis of data from parallel assays
- Representations of DNA binding specificity and motif discovery algorithms
- Predictive modeling of gene regulatory networks using machine learning
Applications are due by March 1st. For more information visit the course website.
